PureTech Presents Promising Preclinical Data from LYT-210 Immuno-Oncology Program at American Association for Cancer Research (AACR) Annual Meeting
PureTech Presents Promising Preclinical Data from LYT-210 Immuno-Oncology Program at
Novel antibody demonstrates highly specific and highly potent targeting of immunosuppressive γδ1 T cells from cancer patients
Enriched in many intractable solid tumors and blood of cancer patients, γδ1 T cells represent important new target for cancer immunotherapy
LYT-210 is a novel, fully human monoclonal antibody (mAb) directed against T cells bearing γδ1 receptors, which are known to suppress the anti-tumor immune response. The new research shared at AACR demonstrates that LYT-210 is both highly specific and highly potent, rapidly inducing cell death of immune-suppressive γδ1 T cells, while sparing other T cells that play important roles in a healthy immune response. The research was conducted in vitro using both patient blood and cancer tissue. LYT-210 has potential as either a single agent or in combination with checkpoint inhibitors and other anti-cancer treatments.
"The role of γδ1 T cells in cancer immune suppression has come into sharp focus in recent years. We now know that these cells deploy multiple immunosuppressive signals to dampen the anti-tumor response and enable the cancer to grow and spread," said
γδ1 T cells are upregulated in multiple solid tumors including breast cancer, glioblastoma, melanoma and pancreatic cancer. They suppress the immune response through multiple mechanisms, including blocking effector T cells, hindering antigen-presenting dendritic cells, restricting the anti-tumoral activity of γδ2 T cells and attracting tumor-associated macrophages and myeloid-derived suppressor cells to the tumor microenvironment. Pathogenic γδ1 T cells are distinct from cytotoxic γδ T cells, which are being used for adoptive T cell transfer or therapeutic engagement with bispecific antibodies. Depleting pathogenic γδ1 T cells has the capacity to modulate both innate and adaptive immunity, and their distinct phenotypic and functional properties make them excellent potential therapeutic targets.
For more information, visit www.puretechhealth.com or connect with us on Twitter @puretechh.
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This press release contains statements that are or may be forward-looking statements, including statements that relate to the company's future prospects, developments, and strategies. The forward-looking statements are based on current expectations and are subject to known and unknown risks and uncertainties that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, our expectations regarding the potential therapeutic benefits of our therapeutic candidates, our expectations regarding the potential mechanism of action and related benefits expected from LYT-210 based on the preclinical results presented at AACR, and those risks and uncertainties described in the risk factors included in the regulatory filings for
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