PureTech Presents Data from Phase 1 Trial of LYT-200 Targeting Galectin-9 in Solid Tumors at the ESMO Immuno-Oncology Congress 2023
PureTech Presents Data from Phase 1 Trial of LYT-200 Targeting Galectin-9 in Solid Tumors at the
LYT-200 demonstrates favorable safety profile and anti-tumor activity in combination with anti-PD-1 agent, tislelizumab
Three out of four patients treated so far with head and neck cancers experienced disease control, with one complete response and one partial response observed in the first subset of patients
Initial results are promising, particularly for patients with head and neck cancers, where historical outcomes are poor with response rates of less than 20 percent on current standard-of-care treatments1
The data being presented from an ongoing study including all evaluable patients demonstrate that LYT-200 has a favorable safety profile in all cohorts, including the monotherapy and combination arms, and shows disease control and initial anti-tumor activity in combination with tislelizumab. In the combination cohort, anti-tumor activity was observed in patients with relapsed or refractory head and neck squamous cell carcinoma, a patient population that has historically demonstrated a low response rate to anti-PD-1 agents of around 20 percent and 10 percent with chemotherapy1.
"Galectin-9 is thought to play a foundational role in suppressing immune-mediated activity against tumor cells, and increases in galectin-9 expression have been shown to correlate with aggressive disease and higher mortality, as is seen in patients with head and neck and urothelial cancers," said
The Phase 1/2 clinical trial includes a dose finding/dose escalation phase (part 1) and an expansion cohort phase (part 2) in patients with relapsed and refractory, locally advanced/metastatic solid tumors. In the monotherapy cohort, 20 patients received LYT-200 across seven escalation doses, with dose levels of 0.2 mg/kg to 16 mg/kg once every two weeks or 10 mg/kg once a week. LYT-200 was well-tolerated with no observed dose-limiting toxicities and only low-grade adverse events, as well as long-term disease stabilization exceeding one year in patients with heavily pre-treated pancreatic cancer and in one patient with colorectal cancer. The monotherapy arm of the trial has been completed, and the clinically relevant dose was selected for the Phase 2 portion of the trial.
In the combination arm, 11 patients have been dosed, and the initial subset of all evaluable patients treated so far includes four patients with head and neck cancers and two patients with urothelial cancer. In the evaluable patients with head and neck cancers, disease control was observed in three of the four patients, with one patient experiencing a complete response for nine months, one patient with a deepening partial response for eight months, and one patient with disease stabilization for four months, and treatment in these patients remains ongoing. The two evaluable patients with urothelial cancer experienced disease stabilization for seven months and three months, and both remain on treatment. The combination arm continues to enroll patients with urothelial and head and neck cancers.
"Galectin-9 is a promising target for the treatment of solid tumors, and the initial results from the LYT-200 Phase 1 trial support its clinical potential," said
The poster titled "Phase 1/2 Trial of Galectin-9 Antibody LYT-200 +/- Tislelizumab" will be presented today at
LYT-200 is a fully human IgG4 monoclonal antibody targeting a foundational immunosuppressive protein, galectin-9, for the potential treatment of metastatic/locally advanced solid tumors, including urothelial and head and neck cancers, with otherwise poor survival rates. A wide variety of preclinical data supports the potential clinical efficacy of LYT-200 and the importance of galectin-9 as a target and suggests a potential opportunity for biomarker development.
For more information, visit www.puretechhealth.com or connect with us on X (formerly Twitter) @puretechh.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation those related to our expectations around the design of and the timelines and key milestones associated with clinical trials for LYT-200, including the initial results from the Phase 1 portion of the Phase 1/2 dose escalation and expansion clinical trial in solid tumors, our expectations regarding the potential treatment indications, and
1 Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008 Sep 11;359(11):1116-27. doi: 10.1056/NEJMoa0802656. PMID: 18784101.
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